A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
Antibiotic resistance is a global health crisis, linked to over 4.5 million deaths in 2019, and it continues to undermine
Healthy skin microbiota is a shield against external and internal factors, including solar radiation (SR), chemicals, pollutants, tobacco smoke as
Yeasts represent a very heterogeneous group of organisms widely used by humans since ancient times to make bread, beer, and
Emerging life-threatening multidrug-resistant (MDR) species such as the C. haemulonii species complex, Clavispora lusitaniae (sin. C. lusitaniae), and other Candida species are considered as an increasing risk
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors
Although the transmission of animal viruses, with consequent species jump, represents a serious and constant threat to human health, experimental
Linezolid (LNZ) is a synthetic antibacterial agent of the oxazolidinone class active against Gram-positive and moderately active against a few
Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome
The viral intra-host genetic diversities and interactions with the human genome during decades of persistence remain poorly characterized. In this
Breaking the Pathogenicity of Aspergillus fumigatus: How BET Inhibitor JQ1 Alters Virulence Factors
Aspergillus fumigatus is an opportunistic pathogen capable of causing disease due to its remarkable adaptability to various environmental conditions. The secreted
Discovery of a structural class of antibiotics with explainable deep learning
This paper presents an innovative approach based on deep learning for the discovery of new structural classes of antibiotics. The
Herpes simplex virus type 1 (HSV-1) is a neurotropic human pathogen that establishes a long-term interaction with the infected host.
The intracellular redox state influences the SARS-CoV-2 entry and replication in the host cell. A reducing microenvironment impairs the binding
A balanced ocular microbiota is important for the maintaining of the local homeostasis because it modulates the immune response and,